منابع مشابه
DNA Helicases
DNA helicases are proteins that use the energy of NTP hydrolysis to processively denature duplex DNA.' As such, helicases can be considered similar to other mechanochemical motors that can catalyze directional movement along a polymeric lattice (e.g., microtubule-based motors as kinesin). Acting during DNA replication, helicases convert the duplex DNA to single strands and thereby activate the ...
متن کاملDna Helicases
In all organisms, genetic information is locked within a double helix formed by the two antiparallel deoxyribonucleic acid (DNA) strands. Although double-stranded DNA (dsDNA) is suitable for secure information storage, hydrogen bonds formed between complementary bases impair readout of this information by the cellular machineries that frequently require single-stranded DNA (ssDNA) as the templa...
متن کاملUnraveling DNA helicases
DNA helicases are molecular motor enzymes that use the energy of NTP hydrolysis to separate transiently energetically stable duplex DNA into single strands. They are therefore essential in nearly all DNA metabolic transactions. They act as essential molecular tools for the cellular machinery. Since the discovery of the first DNA helicase in Escherichia coli in 1976, several have been isolated f...
متن کاملDNA Helicases and Human Disease
HELICASES ARE MOTOR PROTEINS THAT UTILIZE THE ENERGY DERIVED from the hydrolysis of nucleoside triphosphates (NTP/dNTP) to disrupt hydrogen-bond interactions in doubleor multi-stranded DNA and RNA. All known helicases are recognized to have at least two intrinsic enzymatic activities: (1) NTP/dNTP-dependent nucleic acid unwinding and (2) DNA/RNA-dependent NTP/dNTP hydrolysis. Unwinding of DNA a...
متن کاملMCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity
As a crucial component of DNA replication licensing system, minichromosome maintenance (MCM) 2-7 complex acts as the eukaryotic DNA replicative helicase. The six related MCM proteins form a heterohexamer and bind with ORC, CDC6, and Cdt1 to form the prereplication complex. Although the MCMs are well known as replicative helicases, their overabundance and distribution patterns on chromatin prese...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1990
ISSN: 0014-5793
DOI: 10.1016/0014-5793(90)81279-w